منابع مشابه
Nucleoside and nucleobase transporters of primary human cardiac microvascular endothelial cells: characterization of a novel nucleobase transporter.
Levels of cardiovascular active metabolites, like adenosine, are regulated by nucleoside transporters of endothelial cells. We characterized the nucleoside and nucleobase transport capabilities of primary human cardiac microvascular endothelial cells (hMVECs). hMVECs accumulated 2-[3H]chloroadenosine via the nitrobenzylmercaptopurine riboside-sensitive equilibrative nucleoside transporter 1 (EN...
متن کاملFunctional Characterization of Two Putative Nucleobase Transporters in Arabidopsis Using Heterologous Complementation in Yeast
Miller, Sara E. M.S., Purdue University, August 2012. Functional Characterization of Two Putative Nucleobase Transporters in Arabidopsis Using Heterologous Complementation in Yeast. Major Professor: George S. Mourad. To identify the substrate profile function for AtNAT5, one of the twelve members of the NAT/NCS2 gene family putatively identified to transport xanthine and/or uric acid, and to id...
متن کاملSix related nucleoside/nucleobase transporters from Trypanosoma brucei exhibit distinct biochemical functions.
Purine nucleoside and nucleobase transporters are of fundamental importance for Trypanosoma brucei and related kinetoplastid parasites because these protozoa are not able to synthesize purines de novo and must salvage the compounds from their hosts. In the studies reported here, we have identified a family of six clustered genes in T. brucei that encode nucleoside/nucleobase transporters. These...
متن کاملMultinuclear Metal Nucleobase Complexes
Of all properties of metal nucleobase complexes, formation of multinuclear species appears to be an outstanding feature. After a brief introduction into well known polymeric metal nucleobase complexes, three aspects recently Studied in our laboratory will be dealt with in more detail: (i) Heteronuclear complexes derived from trans-[(amine)(2)Pt(1-MeC)(2)](2+) (1-MeC=1-methylcytosine). They form...
متن کاملInsights to the evolution of Nucleobase-Ascorbate Transporters (NAT/NCS2 family) from the Cys-scanning analysis of xanthine permease XanQ.
The nucleobase-ascorbate transporter or nucleobase-cation symporter-2 (NAT/NCS2) family is one of the five known families of transporters that use nucleobases as their principal substrates and the only one that is evolutionarily conserved and widespread in all major taxa of organisms. The family is a typical paradigm of a group of related transporters for which conservation in sequence and over...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEMS Microbiology Reviews
سال: 2007
ISSN: 1574-6976
DOI: 10.1111/j.1574-6976.2007.00083.x